Are fusion peptides a good model to study viral cell fusion?
نویسندگان
چکیده
منابع مشابه
Influenza fusion peptides.
The 'fusion peptides' of a group of enveloped viruses that includes influenza, paramyxo-, retro-and filo-viruses are N-terminal regions of their membrane fusion proteins generated by cleavage of non-functional precursors. For the influenza membrane fusion protein, haemagglutinin (HA), the three-dimensional structures of precursor HA, cleaved HA and fusion-activated HA show that the fusion pepti...
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M embrane fusion is a fundamental process in neurotransmission, vesicle trafficking, and infection by enveloped viruses. Mutational studies of class I viral fusion proteins have shown that simply pulling the two membranes together is not sufficient (1–3) to catalyze fusion in a physiological context: in these systems, a specific activity of the membrane-inserted peptides is required for full fu...
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Influenza A viral (IAV) fusion peptides are known for their important role in viral-cell fusion process and membrane destabilization potential which are compatible with those of antimicrobial peptides. Thus, by replacing the negatively or neutrally charged residues of FPs with positively charged lysines, we synthesized several potent antimicrobial peptides derived from the fusogenic peptides (F...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2003
ISSN: 0005-2736
DOI: 10.1016/s0005-2736(03)00168-8